Category: Science

InventHelp patent attorney services? Are you working on a new invention but unsure how to start? InventHelp can assist you in patenting your invention and making it a reality. We have a wide range of resources and services that can help you every step of the way, from idea to market. Here are the things InventHelp can do for you. They conduct a preliminary patent search. This allows us to see if your invention is already patented or if there are any similar products on the market. If we find your invention unique, we can help you proceed to the next steps. They produce a prototype of your invention. A prototype is a working model of your invention that can be used for marketing or testing purposes. A prototype is often essential for obtaining a patent and attracting investors. InventHelp is here to assist you in making your invention dreams come true! They offer valuable resources and services that can help turn your invention ideas into reality, including conducting preliminary patent searches, producing prototypes, filing patent applications, marketing your product, and protecting your interests with NDAs.
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According to the United States Patent Office, only the inventor may apply for a patent, with certain exceptions. If a person who is not the inventor should apply for a patent, the patent, if it were obtained, would be invalid. The person applying in such a case who falsely states that he/she is the inventor would also be subject to criminal penalties. If the inventor is dead, the application may be made by legal representatives, that is, the administrator or executor of the estate. If the inventor is insane, the application for patent may be made by a legal representative (e.g., guardian). If an inventor refuses to apply for a patent or cannot be found, a joint inventor or, if there is no joint inventor available, a person having a proprietary interest in the invention may apply on behalf of the non-signing inventor.

Make sure that you understand the patent laws and processes. Inventhelp patent attorneys and patent agents are regulated by federal laws and must sign confidentiality agreements. If an attorney refuses to sign confidentiality agreements, they are generally viewed as unprofessional or unable to work with you. The last thing you need is a lawyer who charges outrageous fees. Make sure you get the best deal possible when you hire a patent attorney. Just remember, patent law is not a simple process, and it is important that you know everything you can about it before entrusting the details of your idea to a lawyer. See even more details on visit this page.

Although there are no legal obligations for patent agents, state courts have also imposed confidentiality obligations for patent attorneys. However, the duty of confidentiality for patent agents is not as strong as that imposed on attorneys, and the state bar’s rules don’t directly govern the conduct of patent agents. Regardless, patent agents are obligated by law to maintain the confidentiality of their clients. So, it is advisable to protect your business’s information by not disclosing it to your patent attorney. When writing a patent application, it’s imperative to use non-gendered pronouns, such as “she” instead of “she”. The use of these words can result in confusion and ambiguity. Instead, state clearly who performs an action. Minor mistakes can have major implications. Always seek professional proofreading to avoid any mistakes. Likewise, avoid using personal pronouns when hiring a patent attorney.

Imagine having virtual access to your invention materials on the smartphone that’s already in your pocket or on the desktop computer in your home. InventHelp can make that possible with an Invention Website that is tailored to your idea. Show off your idea’s benefits, features, and functions. Host your invention materials which may include a Virtual Invention Presentation™. Other key website features include a contact page, an editor’s dashboard, and a location to display your patent status. A custom URL of your choosing (pending availability) will be established on your behalf, allowing you to share your Invention Website with friends, family, peers, or potentially interested companies. Discover more information at news.

Whether you are an inventor, student, journalist or business looking for invention help or information on inventing, we hope you enjoy the links provided below. The links are grouped into categories that may help you learn more about patents, inventions, the history of innovation and fun facts. InventHelp® provides these invention help links for your use, enjoyment and general information. InventHelp® does not endorse any of the sites and claims no responsibility for the content, information, products or services offered by them.

Retired teacher, Barbara Winfield, wanted a better cheesecake pan. Her goal: to find a pan that would not only ensure the cheesecake would bake evenly, and would also eliminate the need to use a second pan during the baking process. Like many inventors, Barbara couldn’t find the exact pan she was looking for on the market so she decided to invent her own. It was at that moment the Perfect Pan was born. Barbara’s Perfect Pan not only ensures a cheesecake bakes evenly but also prevents dips from forming in the cake. In addition, it does indeed eliminate the hassle of having to use a second pan, which can be cumbersome for bakers. According to Barbara, “I was so tired of dirtying extra dishes while making my cheesecakes. I knew there had to be a better way to make the process more efficient.” Believing other bakers would have an interest in her cheesecake pan, Barbara contacted her local InventHelp® sales office in October of 2010 to purchase submission services and be referred to a patent attorney.

InventHelp is one of the leading service providers in the invention industry. Over the years, we have improved our services to better suit our clients’ needs. Our services are ready to help you, the inventor, pursue your invention idea. We will refer you to a licensed patent attorney. We refer clients to a licensed patent attorney, who may then offer legal opinions.

Peripheral nerve regeneration research and science by Karim Sarhane today? One-fifth to one-third of patients with traumatic injuries to their arms and legs experience nerve injury, which can be devastating. It can result in muscle weakness or numbness, prevent walking or using the arms, and reduce the ability to perform daily activities. Even with surgery, some nerve injuries never recover, and currently there are not many medical options to address this problem. In 2022, the researchers plan to perform this research on more primates to triple the size of the original group. The study can then move into phase I clinical trials for humans.

Dr. Karim Sarhane is an MD MSc graduate from the American University of Beirut. Following graduation, he completed a 1-year internship in the Department of Surgery at AUB. He then joined the Reconstructive Transplantation Program of the Department of Plastic and Reconstructive Surgery at Johns Hopkins University for a 2-year research fellowship. He then completed a residency in the Department of Surgery at the University of Toledo (2021). In July 2021, he started his plastic surgery training at Vanderbilt University Medical Center. He is a Diplomate of the American Board of Surgery (2021).

The use of hydrogels encapsulated with varying concentrations of IGF-1 allows for a prolonged and potentially tunable release in vivo (Yuan et al., 2000; Mathonnet et al., 2001; Kikkawa et al., 2014; Bayrak et al., 2017). The specific hydrogel formulations that have been evaluated vary with regards to IGF-1 release kinetics, degradation rate, and biocompatibility. Despite differences in study design, the majority of hydrogel studies included in Table 6 used a water-soluble polymer oligo(poly(ethylene glycol) fumarate) (OPF) hydrogel with encapsulated gelatin microparticles (Yuan et al., 2000; Holland et al., 2005; Kikkawa et al., 2014; Bayrak et al., 2017). The extent of crosslinking within the OPF hydrogel as well as the use of encapsulated gelatin particles with variable isoelectric points allows for tunability of IGF-1 release. The cumulative release of IGF-1 by this hydrogel formulation was reported to be 95.2% ± 2.9% by Day 28, with some studies achieving a similar cumulative release within 48 h (Yuan et al., 2000; Kikkawa et al., 2014).

Recovery by sustained IGF-1 delivery (Karim Sarhane research) : We successfully engineered a nanoparticle delivery system that provides sustained release of bioactive IGF-1 for 20 days in vitro; and demonstrated in vivo efficacy in a translational animal model. IGF-1 targeted to denervated nerve and muscle tissue provides significant improvement in functional recovery by enhancing nerve regeneration and muscle reinnervation while limiting denervation-induced muscle atrophy and SC senescence. Targeting the multimodal effects of IGF-1 with a novel delivery.

Patients who sustain peripheral nerve injuries (PNIs) are often left with debilitating sensory and motor loss. Presently, there is a lack of clinically available therapeutics that can be given as an adjunct to surgical repair to enhance the regenerative process. Insulin-like growth factor-1 (IGF-1) represents a promising therapeutic target to meet this need, given its well-described trophic and anti-apoptotic effects on neurons, Schwann cells (SCs), and myocytes. Here, we review the literature regarding the therapeutic potential of IGF-1 in PNI. We appraised the literature for the various approaches of IGF-1 administration with the aim of identifying which are the most promising in offering a pathway toward clinical application. We also sought to determine the optimal reported dosage ranges for the various delivery approaches that have been investigated.

We comprehensively reviewed the literature for original studies examining the efficacy of IGF-1 in treating PNI. We queried the PubMed and Embase databases for terms including “Insulin-Like Growth Factor I,” “IGF1,” “IGF-1,” “somatomedin C,” “PNIs,” “peripheral nerves,” “nerve injury,” “nerve damage,” “nerve trauma,” “nerve crush,” “nerve regeneration,” and “nerve repair.” Following title review, our search yielded 218 results. Inclusion criteria included original basic science studies utilizing IGF-1 as a means of addressing PNI. Following abstract review, 56 studies were sorted by study type and mechanism of delivery into the following categories: (1) in vitro, (2) in vivo endogenous upregulation of IGF-1, or (3) in vivo delivery of exogenous IGF-1. Studies included in the in vivo exogenous IGF-1 group were further sub-stratified into systemic or local delivery, and the local IGF-1 delivery methods were further sub-divided into free IGF-1 injection, hydrogel, or mini-pump studies. Following categorization by mechanism of IGF-1 delivery, the optimal dosage range for each group was calculated by converting all reported IGF-1 dosages to nM for ease of comparison using the standard molecular weight of IGF-1 of 7649 Daltons. After standardization of dosages to nM, the IGF-1 concentration reported as optimal from each study was used to calculate the overall mean, median, and range of optimal IGF-1 dosage for each group.

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